Savarin 1Professor

Equipe SBMB - CSPBAT- UMR 7244

UFR Santé, Médecine, Biologie Humaine Université Paris 13
74 rue Marcel Cachin
93017 Bobigny Cedex (France)

 

 

Biographie

Philippe Savarin received an Engineer diploma from the Centrale school of the University of Lille (1997), a master in physical and chemical analysis (1997) and a PhD (2001) in Spectroscopy from the Centrale School of Paris. After a post-doctoral in Orsay University (LEBS), he got a position of associate professor at the Evry University in 2002. He is professor at the Paris 13 University since 2012. He has been the assistant Director of the CSPBAT laboratory between 2014 and 2016 and is the Director since 2016.

 

Recherche

Mots-clés:

  • Metabolomics by NMR
  • Liver
  • Protein Structure
  • Protein Protein interaction

Techniques

NMR spectroscopy, metabolomics, multivariate statistics analysis, protein production and purification.

Publications

2018:

  • NMR metabolomic signatures reveal predictive plasma metabolites associated with long-term risk of developing breast cancer. Lécuyer L, Victor Bala A, Deschasaux M, Bouchemal N, Nawfal Triba M, Vasson MP, Rossary A, Demidem A, Galan P, Hercberg S, Partula V, Le Moyec L, Srour B, Fiolet T, Latino-Martel P, Kesse-Guyot E, Savarin P, Touvier M., Int J Epidemiol. 2018 Jan 19. doi: 10.1093/ije/dyx271.

2017:

  • Determination of candidate metabolite biomarkers associated with recurrence of HCV-related hepatocellular carcinoma. Liu Z, Nahon P, Li Z, Yin P, Li Y, Amathieu R, Ganne-Carrié N, Ziol M, Sellier N, Seror O, Le Moyec L, Savarin P, Xu G., Oncotarget. 2017 Dec 15;9(5):6245-6258.
  • Identification of a discriminative metabolomic fingerprint of potential clinical relevance in saliva of patients with periodontitis using 1H nuclear magnetic resonance (NMR) spectroscopy. Rzeznik M, Triba MN, Levy P, Jungo S, Botosoa E, Duchemann B, Le Moyec L, Bernaudin JF, Savarin P, Guez D., PLoS One. 2017 Aug 24;12(8):e0182767. doi: 10.1371/journal.pone.0182767. eCollection 2017.
  • Nuclear magnetic resonance metabolomics and human liver diseases: The principles and evidence associated with protein and carbohydrate metabolism. Le Moyec L, Triba MN, Nahon P, Bouchemal N, Hantz E, Goossens C, Amathieu R, Savarin P., Biomed Rep. 2017 Apr;6(4):387-395. doi: 10.3892/br.2017.868. Epub 2017 Mar 3.
  • A new model of short acceleration-based training improves exercise performance in old mice. Niel R, Ayachi M, Mille-Hamard L, Le Moyec L, Savarin P, Clement MJ, Besse S, Launay T, Billat VL, Momken I., Scand J Med Sci Sports. 2017 Dec;27(12):1576-1587. doi: 10.1111/sms.12809. Epub 2016 Dec 20.

2016:

  • Application of LC-MS-based metabolomics method in differentiating septic survivors from non-survivors. Liu Z, Yin P, Amathieu R, Savarin P, Xu G., Anal Bioanal Chem. 2016 Nov;408(27):7641-7649. Epub 2016 Sep 10.
  • Tunable Design of Gold(III)-Doxorubicin Complex-PEGylated Nanocarrier. The Golden Doxorubicin for Oncological Applications. Moustaoui H, Movia D, Dupont N, Bouchemal N, Casale S, Djaker N, Savarin P, Prina-Mello A, de la Chapelle ML, Spadavecchia J., ACS Appl Mater Interfaces. 2016 Aug 10;8(31):19946-57. doi: 10.1021/acsami.6b07250. Epub 2016 Jul 26.

2015:

  • PLS/OPLS models in metabolomics: the impact of permutation of dataset rows on the K-fold cross-validation quality parameters Triba, M. N., Le Moyec, L., Amathieu, R., Goossens, C., Bouchemal, N., Nahon, P., Rutledge, D. N.,
    Savarin, P. Mol Biosyst 11, 13-19, 2015.

2014:

  • Metabolic impact of anti-angiogenic agents on U87 glioma cells Mesti, T., Savarin, P., Triba, M. N., Le Moyec, L., Ocvirk, J., Banissi, C., Carpentier, A. F. PLoS One 9, e99198, 2014.
  • Serum 1H-NMR Metabolomic Fingerprints of Acute-On-Chronic Liver Failure in Intensive Care Unit Patients with Alcoholic Cirrhosis Amathieu, R., Triba, M. N., Nahon, P., Bouchemal, N., Kamoun, W., Haouache, H., Trinchet, J. C., Savarin, P., Le Moyec, L., Dhonneur, G. PLoS One 9, e89230, 2014.

2013:

  • Structural basis for the association of MAP6 with microtubules and its regulation by calmodulin Lefevre, J., Savarin, P., Gans, P., Hamon, L., Clement, M. J., David, M. O., Bosc, C., Andrieux, A., Curmi, P. A. J Biol Chem., 288(34), 24910-22, 2013.

2012:

  • Macromolecular crowding regulates assembly of mRNA stress granules after osmotic stress: new role for compatible osmolytes Bounedjah, O., Hamon, L., Savarin, P., Desforges, B., Curmi, P. A., Pastre, D.,
    J Biol Chem 287, 2446-2458, 2012.
  • Mapping the conformational stability of maltose binding protein at the residue scale using nuclear magnetic resonance hydrogen exchange experiments. Merstorf, C., Maciejak, O., Mathe, J., Pastoriza-Gallego, M., Thiebot, B., Clement, M. J., Pelta, J., Auvray, L., Curmi, P. A., Savarin, P. Biochemistry 51, 8919-8930, 2012.
  • Phosphorylation controls the interaction of the connexin43 C-terminal domain with tubulin and microtubules
    Saidi Brikci-Nigassa, A., Clement, M. J., Ha-Duong, T., Adjadj, E., Ziani, L., Pastre, D., Curmi, P. A., Savarin, P.
    Biochemistry 51, 4331-4342, 2012.

2011:

  • Gap junctions favor normal rat kidney epithelial cell adaptation to chronic hypertonicity Desforges, B., Savarin, P., Bounedjah, O., Delga, S., Hamon, L., Curmi, P. A., and Pastre, D., Am J Physiol Cell Physiol 301, C705-716, 2011.
    Rapid assembly and collective behavior of microtubule bundles in the presence of polyamines Hamon, L., Savarin, P., Curmi, P. A., and Pastre, D. Biophys J 101, 205-216, 2011.
  • The C terminus of tubulin, a versatile partner for cationic molecules: binding of Tau, polyamines, and calcium
    Lefevre, J., Chernov, K. G., Joshi, V., Delga, S., Toma, F., Pastre, D., Curmi, P. A., Savarin, P., J Biol Chem 286, 3065-3078, 2011.

 

Enseignement

Professor in chemistry