juliaMaître de conférences

UFR SMBH, Laboratoire CSPBAT, Equipe Chimie Bioorganique et Synthèse, Bureau 332
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Biographie

Julia DESCHAMP a effectué ses études supérieures à l’Université Pierre et Marie Curie (UPMC, Paris). Julia DESCHAMP a ensuite poursuivi par une thèse à l‘Université catholique de Louvain (Belgique) sous la direction du Professeur Olivier RIANT. En 2008, Julia DESCHAMP a obtenu son doctorat sur le développement d’une réaction domino de réduction-aldolisation catalysée par un complexe chiral de cuivre (I). Elle a ensuite poursuivi par un poste d’attaché temporaire d’enseignement et de recherche à l’Institut Parisien de Chimie Moléculaire (UMR CNRS 7201, UPMC, Paris) dans l’équipe du Professeur Matthieu Sollogoub. Julia DESCHAMP a ensuite effectuée deux stages post-doctoraux tout d’abord, à l’Institut de Chimie Moléculaire et des Matériaux d’Orsay dans l’équipe du Dr. Emmanuelle Schulz (UMR CNRS 8182, Université Paris-Sud, Orsay), puis à L’Institut des Substances Naturelles dans l’équipe du Professeur Jean-Marie BEAU (UPR CNRS 2301,Gif-sur-Yvette). En 2011, Julia DESCHAMP a été nommé Maitre de Conférences à l’Université Paris 13 dans le Laboratoire de Chimie, Structures et Propriétés Biologiques d’Agents Thérapeutiques (UMR CNRS 7244) dirigé par le Professeur Véronique MIGONNEY, dans l’équipe du Professeur Marc LECOUVEY. Son domaine d’expertise est la synthèse organique et la catalyse asymétrique.

Biography

Julia DESCHAMP graduated from Université Pierre et Marie Curie (UPMC, Paris). Then, Julia DESCHAMP started her doctoral studies under the supervision of Professor Olivier RIANT at Université catholique de Louvain (Belgium). In 2008, she received her PhD, for her works on domino reductive-aldol reaction catalyzed by a chiral copper (I) complex. After three year - Post-doctoral fellowships in different universities, she obtained an academic position as assistant professor in 2011 at Université Paris 13 (UMR CNRS 7244). Her area of expertise is organic synthesis and catalysis. Her research interests focus on synthetic methodology, including the design and synthesis of novel chiral organocatalysts.

Thème de recherche/ Research topic

Développement méthodologique pour la synthèse d’organophosphorés. Application pour la synthèse de composés d'intérêt et en catalyse asymétrique.

Methodological develpment  for the synthesis of organophosphorus derivatives. Application for the synthesis of biological relevant organophosphorus compounds and in asymmetric catalysis

Publications

Julia Deschamp est co-auteur de 19 publications dans des journaux internationaux, 2 proceedings et de 1 brevet (facteur H : 11  ; 362 citations sans auto-citation)

les dernières publications significatives :

One-Pot Synthesis of Phosphinylphosphonate Derivatives and Their Anti-Tumor Evaluations. J. Dussart-Gautheret, J. Deschamp, T. Legigan, M. Monteil, E. Migianu-Griffoni, M. Lecouvey, Molecules 2021, 26, 7609. DOI: 10.3390/molecules26247609. Impact factor : 4.412 This article belongs to the Special Issue Featured Papers in Medicinal Chemistry

Formation of 1-Hydroxymethylene-1,1-Bisphosphinates through the Addition of a Silylated Phosphonite on various Trivalent Derivatives. J. Dussart, J. Deschamp, M. Monteil, O. Gager, T. Legigan, E. Migianu-Griffoni, M. Lecouvey J. Org. Chem. 2020 85, 14559-14569. DOI: 10.1021/acs.joc.0c01182. Impact factor : 4.745 this article is part of a special issue "the new golden age of organophosphorus chemistry"

From Industrial Method to the Use of Silylated P(III) Reagents for the Synthesis of Relevant Phosphonylated Molecules. J. Dussart, J. Deschamp, E. Migianu-Griffoni, M. Lecouvey. Org. Process Res. Dev. 2020, 24, 637-651. DOI : 10.1021/acs.oprd.9b00490 this article is part of a special issue "a Taste of Current French Organic Chemistry" Impact factor : 3.023

A General Protocol for the Synthesis of H-α-Hydroxyphosphinates. J. Dussart, J. Deschamp, M. Monteil, O. Gager, E. Migianu-griffoni, M. Lecouvey . Synthesis, 2019, 51, 421-432. DOI: 10.1055/s-0037-1610274. Impact factor : 2.867

A convenient synthetic route towards H-bisphosphinates. J. Dussart, N. Guedeney, J. Deschamp, M. Monteil, O. Gager, T. Legigan, E. Migianu-Griffoni, M. Lecouvey. Org. Biomol. Chem., 2018, 16, 6969-6979. DOI : 10.1039/C8OB01878B.  Impact factor : 3,490

Bifunctional Tripeptide with a Phosphonic Acid as a Bronsted Acid for Michael Addition: Mechanistic Insights: Cortes-Clerget, M.; Jover, J.; Dussart, J.; Kolodziej, E.; Monteil, M.; Migianu-Griffoni, E.; Gager, O.; Deschamp, J.; Lecouvey, M., Chem. Eur. J. 2017, 23, 6654-6662. DOI : 10.1002/chem.201700604  Impact factor : 5,160

Novel Easily Recyclable Bifunctional Phosphonic Acid Carrying Tripeptides For The Stereoselective Michael Addition Of Aldehyde With Nitroakenes: Cortes-Clerget, M. ; Gager, O. ; Monteil, M. ; Migianu-Griffoni, E. ; Pirat, J.L. ; Deschamp, J. ; Lecouvey, M. Adv. Synth. Catal. 2016, 358, 34-40.  DOI : 10.1002/adsc.201500794 Impact factor : 5,646

Brevet

Nouveau complexe métallique chiral et son utilisation pour des réactions d’hydroamination énantiosélectives
Schulz, E.; Collin,  J.;  Hannedouche,  J.;  Eyglunent,  C.;  Deschamp,  J. WO2011101563A1.

Enseignement

PACES, Licence Science de la vie (L1, L2, L3)

 

Toutes les publications

 

Structural characterization and in vitro biological exploration of phytoconstituents isolated from a chloroform extract of Rauvolfia vomitoria (Apocynaceae) root bark from Côte d’Ivoire - Ziale, D. A. E.; Ngaman Kouassi, K. C. C.; Deschamp, J.; Bouchemal, N.; Palama, T. L.; Lecouvey, M.; Mamyrbekova Bekro, J. A.; Bekro, Y. A., Journal of Pharmacognosy and Phytochemistry 2023, 12, 06-14. doi: 10.22271/phyto.2023.v12.i1a.14541 (IF : 5.52)

One-Pot Synthesis of Phosphinylphosphonate Derivatives and Their Anti-Tumor Evaluations. J. Dussart-Gautheret, J. Deschamp, T. Legigan, M. Monteil, E. Migianu-Griffoni, M. Lecouvey, Molecules 2021, 26, 7609. DOI: 10.3390/molecules26247609. Impact factor : 4.412 This article belongs to the Special Issue Featured Papers in Medicinal Chemistry

Synthesis and Preliminary Anticancer Evaluation of New Triazole Bisphosphonate-based Isoprenoid Biosynthesis Inhibitors. T. Legigan, E. Migianu-Griffoni, M.A. Abdenour, A. Descamps, J. Deschamp, O. Gager, M. Monteil, F. Barbault, M. Lecouvey, Eur. J. Med. Chem. 2021, 214,133241. DOI : 10.1016/j.ejmech.2021.113241. Impact factor : 5.572

Formation of 1-Hydroxymethylene-1,1-Bisphosphinates through the Addition of a Silylated Phosphonite on various Trivalent Derivatives. J. Dussart-Gautheret, J. Deschamp, M. Monteil, O. Gager, T. Legigan, E. Migianu-Griffoni, M. Lecouvey J. Org. Chem. 2020 85, 14559-14569 DOI: 10.1021/acs.joc.0c01182. Impact factor : 4.745 this article is part of a special issue "the new golden age of organophosphorus chemistry"

joceah.2020.85.issue 22.largecover

From Industrial Method to the Use of Silylated P(III) Reagents for the Synthesis of Relevant Phosphonylated Molecules. J. Dussart, J. Deschamp, E. Migianu-Griffoni, M. Lecouvey. Org. Process Res. Dev. 2020, 24,637-651.DOI : 10.1021/acs.oprd.9b00490 this article is part of a special issue "a Taste of Current French Organic Chemistry" Impact factor : 3.327

OPRD cover grand

A General Protocol for the Synthesis of H-α-Hydroxyphosphinates. J. Dussart, J. Deschamp, M. Monteil, O. Gager, E. Migianu-griffoni, M. Lecouvey . Synthesis, 2019, 51, 421-432. DOI: 10.1055/s-0037-1610274. Impact factor : 2.867

A convenient one-pot synthesis of 1-hydroxymethylene-1,1-bisphosphinic acids. N. Guedeney, J. Dussart, J. Deschamp, M. Ouestati, E. Migianu-Griffoni, M. Lecouvey. Phosphorus Sulfur Silicon Relat. Elem. 2019, 194, 323-325. DOI: 10.1080/10426507.2018.1540001. Impact factor : 0,674

A convenient synthetic route towards H-bisphosphinates. J. Dussart, N. Guedeney, J. Deschamp, M. Monteil, O. Gager, T. Legigan, E. Migianu-Griffoni, M. Lecouvey. Org. Biomol. Chem., 2018, 16, 6969-6979. DOI : 10.1039/C8OB01878B.  Impact factor : 3,490

Bifunctional Tripeptide with a Phosphonic Acid as a Bronsted Acid for Michael Addition: Mechanistic Insights: Cortes-Clerget, M.; Jover, J.; Dussart, J.; Kolodziej, E.; Monteil, M.; Migianu-Griffoni, E.; Gager, O.; Deschamp, J.; Lecouvey, M., Chem. Eur. J. 2017, 23, 6654-6662. DOI : 10.1002/chem.201700604  Impact factor : 5,160

Novel Easily Recyclable Bifunctional Phosphonic Acid Carrying Tripeptides For The Stereoselective Michael Addition Of Aldehyde With Nitroakenes: Cortes-Clerget, M. ; Gager, O. ; Monteil, M. ; Migianu-Griffoni, E. ; Pirat, J.L. ; Deschamp, J. ; Lecouvey, M. Adv. Synth. Catal. 2016, 358, 34-40.  DOI : 10.1002/adsc.201500794 Impact factor : 5,646

Towards potential nanoparticle contrast agents: Synthesis of new functionalized PEG bisphosphonates: Kachbi-Khelfallah, S.; Monteil, M.; Cortes-Clerget, M.; Migianu-Griffoni, E.; Pirat, J. L.; Gager, O.; Deschamp, J.; Lecouvey, M., Beilstein J. Org. Chem. 2016, 12, 1366-1371 Impact factor : 2.337

M. CORTES-CLERGET, O. GAGER, M. MONTEIL, E. MIGIANU-GRIFFONI, J. DESCHAMP, M. LECOUVEY, Phosphorus Sulfur Silicon Relat. Elem. 2016, 191, 1593-1594. . IF 2015: 0.723

Synthesis of novel polymerizable molecules bearing bisphosphonate: Kachbi-Khelfallah, S ; Monteil, M ; Deschamp, J ; Gager, O ; Migianu-Griffoni, E ; Lecouvey, M. Org. Biomol. Chem. 2015, 13, 11382-11392. Impact factor : 3.559

An easy route toward enantio-enriched polycyclic derivatives via an asymmetric domino conjugate reduction-aldol cyclization catalyzed by a chiral Cu(I) complex. Deschamp, J.; Hermant, T.; Riant, O. Tetrahedron 2012, 68, 3457-3467.  Impact factor : 2.803

Towards a stable noeuromycin analog with a D-manno configuration: synthesis and glycosidase inhibition of D-manno-like tri- and tetrahydroxylated azepanes. Deschamp, J.; Mondon, M.; Nakagaw, S.; Kato, A.; Alonzi, D.S.; Butters, T.D.; Zhang, Y.; Sollogoub, M.; Blériot, Y. Bioorg. Med. Chem. 2012, 20, 641-649. Impact factor : 2.903

Cavitand supported tetraphosphine: cyclodextrin offers a useful platform for Suzuki-Miyaura cross-coupling. Zaborova, E.; Deschamp, J.; Guieu, S.; Blériot, Y. ; Poli, G. ; Ménand, M. ; Madec, D. ; Prestat, G. ; Sollogoub, M. Chem. Comm. 2011, 47, 9206-9208. Impact factor : 6.169

Easy routes towards chiral lithium binaphthylamido catalysts for the asymmetric hydroamination of amino-1,3-dienes and aminoalkenes. Deschamp, J.; Collin, J. ; Hannedouche, J. ; Schulz, E. Eur. J. Org. Chem. 2011, 3329-3338. Impact factor : 3.329

Simple chiral diaminobinaphtyl silithium satls for intramolecular catalytic asymmetric hydroamination of amino-1,3-dienes. Deschamp, J.; Olier, C.; Schulz, E.; Guillot, R.; Hannedouche, J.; Collin, J. Adv. Synth. Catal. 2010, 352, 2171-2176. Impact factor : 5.25

An Efficient Construction of Polycyclic Derivatives via a High Selective CuI-Catalyzed Domino Reductive-Aldol Cyclization. Deschamp, J.; Riant, O. Org. Lett. 2009, 11, 1217-1220. Impact factor : 5.42

Copper (I) Catalyzed Enantio- and Diastereoselective Tandem Reductive Aldol Reaction.Chuzel, O.; Deschamp, J.; Chausteur, C.; Riant, O. Org. Lett. 2006, 8, 5943-5946. Impact factor : 4.659

Highly Diastereo- and Enantioselective Copper-Catalyzed Domino Reduction/Aldol Reaction of Ketones with Methyl Acrylate. Deschamp, J.; Chuzel, O.; Hannedouche, J.; Riant, O. Angew. Chem. Int. Ed. 2006, 45, 1292-1297 (VIP). Impact factor : 10.232