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BOUANANI, S.; ZEGGAR, M.; LECOUVEY, M., Isolation, characterization, and valorization of hemicelluloses from olive solid residue as biomaterial, partial kaolin hydrolysis, and antiproliferative activity. Biomass Conversion and Biorefinery 2023. Doi : Impact factor : 4.05

JIANG, Y.; BARDAUD, J.-X.; AYADI, N.; LECOUVEY, M.; HOUÉE-LEVIN, C.; BERDEN, G.; OOMENS, J.; SCUDERI, D., Oxidation of designed model peptides containing methionine, proline and glutamic acid investigated by tandem mass spectrometry and IRMPD spectroscopy. Int. J. Mass Spectrom. 2023, 487, 117029. DOI / Impact factor : 2

ZIALE, D.A.E ; N’GAMAN-KOUASSI, K.C.C. ; DESCHAMP, J. ; BOUCHEMAL, N. ; PALAMA, T.L. ; LECOUVEY, M ; MAMYRBEKOVA-BEKRO, J.A. ; BEKRO, Y-A. Structural characterization and in vitro biological exploration of phytoconstituents isolated from a chloroform extract of Rauvolfia vomitoria (Apocynaceae) root bark from Côte d’Ivoire. J. Pharmacogn. Phytochem. 2023, 12, 6-14. DOI :10.22271/phyto.2023.v12.i1a.14541 Impact factor : RJIF 5.52

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BEKRO, Y.-A.; LECOUVEY, M.; TOMI, F.; BIGHELLI, A.; MAMYRBEKOVA, J. A.; MONTEIL, M.; KAMBIRE, D. A.; OUATTARA, Z. A.; KOUAME, C. Chemical Composition and Biological Activity of Guarea cedrata (A. Chev.) Pellegr. Leaf and Root Bark Essential Oil. Int. J. Biochem. Res. Rev. 2022, 27-35. Impact factor : 2.26

JIANG, Y.; INDRAJITH, S.; PEREZ MELLOR, A. F.; BÜRGI, T.; LECOUVEY, M; CLAVAGUÉRA, C.; BODO, E.; HOUÉE-LEVIN, C.; LOIRE, E.; BERDEN, G.; OOMENS, J.; SCUDERI, D. Final Products of One-Electron Oxidation of Cyclic Dipeptides Containing Methionine Investigated by IRMPD Spectroscopy: Does the Free Radical Choose the Final Compound? J. Phys. Chem. B 2022126, 10055–10068 Impact factor : 3.466

PRANGÉ, T.; COLLOC’H, N.; DHAUSSY, A-C.; LECOUVEY, M.; MIGIANU-GRIFFONI, E.; GIRARD, E. Behavior of B- and Z-DNA Crystals under High Hydrostatic Pressure Crystals 2022, 12, 871. DOI : 10.3390/cryst12060871. Impact factor : 2.589

SABAT, N.; OUARTI,A.; MIGIANU-GRIFFONI, E.; LECOUVEY, M.; FERRARIS,O.; GALLIER,F.; PEYREFITTE, C.; LUBIN-GERMAIN, N.; UZIEL, J. Synthesis, antiviral and antitumor activities investigations of a series of Ribavirin C-nucleoside analogue prodrugs. Bioorg. Chem. 2022, 122, 105723. DOI: 10.1016/j.bioorg.2022.105723 Impact factor : 5.275


DUSSART-GAUTHERET, J.; DESCHAMP, J.; LEGIGAN, T.; MONTEIL, M.; MIGIANU-GRIFFONI, E.; LECOUVEY, M. One-Pot Synthesis of Phosphinylphosphonate Derivatives and Their Anti-Tumor Evaluations. Molecules 2021, 26, 7609. DOI: 10.3390/molecules26247609. This article belongs to the Special Issue Featured Papers in Medicinal Chemistry. Impact factor : 4.412

KARPATI, S.; HUBERT, V.; HRISTOVSKA, I.; LEROUGE, F.; CHAPUT, F.; BRETONNIERE, Y.; ANDRAUD, C.; BANYASZ, A.; MICOUIN, G.; MONTEIL, M.; LECOUVEY, M.; MERCEY-RESSEJAC, M.; DEY, A.K.; MARCHE, P.N.; LINDGREN, M.; PASCUAL, O.; WIART, M.; PAROLA, S. Hybrid Multimodal Contrast Agent for Multiscale in vivo Investigation of Neuroinflammation. Nanoscale, 2021, 13, 3767 Impact factor : 6.895

LEGIGAN, T.; MIGIANU-GRIFFONI, E.; ABDENOUR, M. A.; DESCAMPS, A.; DESCHAMP, J.; GAGER, O.; MONTEIL, M.; BARBAULT, F.; LECOUVEY, M. Synthesis and Preliminary Anticancer Evaluation of New Triazole Bisphosphonate-based Isoprenoid Biosynthesis Inhibitors. Eur. J. Med. Chem. 2021, 214,133241. DOI : 10.1016/j.ejmech.2021.113241. Impact factor : 5.572



DUSSART-GAUTHERET, J.; DESCHAMP, J.; MONTEIL, M.; GAGER, O.; LEGIGAN, T.; MIGIANU-GRIFFONI, E.; LECOUVEY, M. Formation of 1-Hydroxymethylene-1,1-Bisphosphinates through the Addition of a Silylated Phosphonite on various Trivalent Derivatives. J. Org. Chem. 2020, 85, 14559-14569. DOI: 10.1021/acs.joc.0c01182. this article is part of a special issue "the new golden age of organophosphorus chemistry" Impact factor : 4.745

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BRERO, F.; BASINI, M.; AVOLIO, M.; ORSINI, F.; AROSIO, P.; SANGREGORIO, C.; INNOCENTI, C.; GUERRINI, A.; BOUCARD, J.; ISHOW, E.; LECOUVEY, M.; FRESNAIS, J.; LARTIGUE, L.; LASCIALFARI, A., Coating Effect on the (1)H-NMR Relaxation Properties of Iron Oxide Magnetic Nanoparticles. Nanomaterials 2020, 10, 1660. DOI : Impact factor : 4.324

DUSSART, J.; DESCHAMP, J.; MIGIANU-GRIFFONI, E.; LECOUVEY, M., From Industrial Method to the Use of Silylated P(III) Reagents for the Synthesis of Relevant Phosphonylated Molecules. Org. Process Res. Dev. 2020, 24, 637-651.DOI: 10.1021/acs.oprd.9b00490. this article is part of a special issue "a Taste of Current French Organic Chemistry" Impact factor : 3.327

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SABAT, N.; MIGIANU-GRIFFONI, E.; TUDELA, T.; LECOUVEY, M.; KELLOUCHE, S.; CARREIRAS, F.; GALLIER, F.; UZIEL, J.; LUBIN-GERMAIN, N., Synthesis and antitumor activities investigation of a C-nucleoside analogue of ribavirin. Eur. J. Med. Chem. 2020, 188, 112009. DOI : 10.1016/j.ejmech.2019.112009. Impact factor : 5.572


F. CHAPUT, F. LEROUGE, A.L. BULIN, D. AMANS, M. ODZIOMEK, A.C. FAURE, M. MONTEIL, I. DOZOV, S. PAROLA, F. BOUQUET, M. LECOUVEY, P. DAVIDSON, C. DUJARDIN. Liquid-crystalline suspensions of photosensitive paramagnetic CeF3 nanodiscs. Langmuir 2019, 35, 16256-16265. DOI: 10.1021/acs.langmuir.9b02335. Impact factor : 3,683

Z. JAAFAR, S. CHNITI, A. BEN SASSI, H. DZIRI, S. MARQUE, M. LECOUVEY, R. GHARBI, M. MSADDEK. Design and microwave-assisted synthesis of dimers of 1,5-benzodiazepine-1,2,3-triazole hybrids bearing alkyl/aryl spacers and their biological assessment. J. Mol. Struc. 2019, 1195, 689-701. Impact factor : 2,011

N. GUEDENEY, J. DUSSART, J. DESCHAMP, M. OUESTATI, E. MIGIANU-GRIFFONI, M. LECOUVEY. A convenient one-pot synthesis of 1-hydroxymethylene-1,1-bisphosphinic acids. Phosphorus Sulfur Silicon Relat. Elem. 2019, 194, 323-325DOI: 10.1080/10426507.2018.1540001. Impact factor : 0,674

J. DUSSART, J. DESCHAMP, M. MONTEIL, O. GAGER, E. MIGIANU-GRIFFONI, M. LECOUVEY. A General Protocol for the Synthesis of H-α-Hydroxyphosphinates. Synthesis, 2019, 51, 421-432. DOI: 10.1055/s-0037-1610274. Impact factor : 2,722

B. B. BOUA, M. A. C. OULAGUEHI, G. R. M. KABRAN, J. A. MAMYRBEKOVA-BEKRO1, M. LECOUVEY And Y.-A. BEKRO. Chemical Composition And Anticancer Activity Of Daldinia Concentrica (Xylariaceae). World Journal of Pharmaceutical Research. 2019, 8, 257-264. DOI: 10.20959/wjpr20191-13874

H. GUESMIA, O. HADDAD, K. BASSAND, R. GHARBI, M. MSADEK, F. CHAUBET, M. LECOUVEY, R. MOUNIR MAAROUFI, H. HLAWATY. New Synthesized Derivatives from N-Substituted-4-Oxo-[1] Benzopyrano [4,3-c] Pyrazole Influenced Proliferation, Viability, Spreading and Invasion of Human Liver Tumor Cells. International Journal of Sciences: Basic and Applied Research 2019, 42, 167-185.



L. GUESSAN BI GOBLE, B. KADJA AMANI, K. COTTET, M. LECOUVEY, J. A. MAMYRBEKOVA-BEKRO, Y-A. BEKRO. Bio-guided anti-cariogenic and phytochemical valorization of Guiera senegalensis and Pseudocedrela kotschyi stem extracts. J. Med. Plants Res. 2018, 12, 500-507.

J. DUSSART, N. GUEDENEY, J. DESCHAMP, M. MONTEIL, O. GAGER, T. LEGIGAN, E. MIGIANU-GRIFFONI, M. LECOUVEY. A convenient synthetic route towards H-bisphosphinates. Org. Biomol. Chem., 2018, 16, 6969-6970. DOI : 10.1039/C8OB01878B. Impact factor : 3,423

S. CHNITI, A. NSIRA, S. KHOUAJA, A. MECHRIA, R. GHARBI, M. MSADDEK, M. LECOUVEY. Highly diastereoselective synthesis of rigid 3-enamino-1,5-benzodiazepines. Arkivoc 2018, part v, 283-295.   Impact factor : 1,048

F. MPAMBANI, A.K.O. ÅSLUND, F. LEROUGE, S. NYSTRÖM, N. REITAN, E.M. HUUSE, M. WIDERØE, F. CHAPUT, C. MONNEREAU, C. ANDRAUD, M. LECOUVEY, S. HANDRICK, S. PROKOP, F.L. HEPPNER, P. NILSSON, P. HAMMARSTRÖM, M. LINDGREN, S. PAROLA.Two-Photon Fluorescence and Magnetic Resonance Specific Imaging of Aβ Amyloid Using Hybrid Nano-GdF3 Contrast Media. ACS Appl. Bio Mater. 2018 1, 462-472. 

M. MONTEIL, H. MOUSTAOUI, G. PICARDI F. OUIDAT, N. DJAKER, M. LAMY DE LA CHAPELLE, M. LECOUVEY, J. SPADAVECCHIA. Polyphosphonate ligands: from synthesis to design of Hybrid PEGylated Nanoparticles toward phototherapy studies. J. Colloid Interface Sci. 2018 513, 205-213. Impact factor : 4,233


M.B. HADDADA, F. AOUIDAT, M. MONTEIL, M. LECOUVEY, M. LAMY DE LA CHAPELLE, J. SPADAVECCHIA. A simple assay for direct colorimetric detection of prostatic acid phosphatase (PAP) at fg levels using biphosphonated loaded PEGylated gold nanoparticles. Frontiers in Laboratory Medecine 2017 1 186-191.

C. LINOT, J. POLY, J. BOUCARD, D. POULIQUEN, S. NEDELLEC, P. HULIN, N. MAREC, P. AROSIO, A. LASCIALFARI, A. GUERRINI, C. SANGREGORIO, M. LECOUVEY, L. LARTIGUE, C. BLANQUART, E. ISHOW. PEGylated Anionic Magnetofluorescent Nanoassemblies: Impact of Their Interface Structure on Magnetic Resonance Imaging Contrast and Cellular Uptake. ACS Appl. Mater. Interfaces 2017, 9, 14242-14257. Impact factor : 7,504

Z. HASSANI, A. SALEH, S. TURPAULT, S. KHIATI, W. MORELLE, J. VIGNON, J-P. HUGNOT, E. URO-COSTE, P. LEGRAND, M. DELAFORGE, S. LOISEAU, L. CLARION, M. LECOUVEY, J-N VOLLE, D. VIRIEUX, J-L PIRAT, H. DUFFAU, N. BAKALARA. Phostine PST3.1a Targets MGAT5 and Inhibits Glioblastoma Initiating Cell Invasiveness and Proliferation Impact factor : 4,974

M. CORTES-CLERGET, J. JOVER, J. DUSSART, E. KOLODZIEJ, M. MONTEIL, E. MIGIANU-GRIFFONI, O. GAGER, J. DESCHAMP, M. LECOUVEY. Bifunctional Tripeptide with a Phosphonic Acid as a Brønsted Acid for Michael Addition: Mechanistic Insights. Chem. Eur. J. 2017, 23, 6654-6662. Impact factor : 5,771

M . MONTEIL, M. LECOUVEY, D. LANDY, S. RUELLAN, I. MALLARD. Cyclodextrins: A promising drug delivery vehicle for bisphosphonate. Carbohydrate Polymers 2017 156, 285-293. Impact factor : 4,811

GRM KABRAN, JA MAMYRBEKOVA-BEKRO, JL PIRAT, M LECOUVEY, O SAINTE-CATHERINE, N SOMMERER, A VERBAERE, EMEUDEC, YA BEKRO. UPLC-MS quantification and Anticancer Potential of Ximenia Americana Hydro-Acetonic Crude Extract Leaves.Der Chemica Sinica 2017, 8, 70-74. Impact Factor 0,676


S. KACHBI-KHELFALLAH, M. MONTEIL, M. CORTES-CLERGET, E. MIGIANU-GRIFFONI, J-L. PIRAT, O. GAGER, J. DESCHAMP, M. LECOUVEY. Towards potential nanoparticle contrast agents: Synthesis of new functionalized PEG bisphosphonates. Beilstein J. Org. Chem. 2016, 12, 1366-1371. Impact Factor 2.7

M. CORTES-CLERGET, O. GAGER, M. MONTEIL, E. MIGIANU-GRIFFONI, J. DESCHAMP, M. LECOUVEY, Phosphorus Sulfur Silicon Relat. Elem. 2016, 191, 1593-1594. . IF 2015: 0.723

A. B. KADJA, Y-A. BEKRO, J-L. PIRAT, J. AKHANOVNA MAMYRBEKOVA-BEKRO, J-N. VOLLE, M. LECOUVEY, M-H. BOYER-LAVERGNE. Chemical Constituents and in Vitro Biological Screening of Hydroacetonic Extracts of 3 African Toothpicks. International Journal of Green and Herbal Chemistry (IJGHC) 2016 ; Sec. A; 5, 201-208 Impact Factor 1.8

L. SEMERANO , E. DUVALLET, N. BELMELLAT, N. MARIVAL, N. SCHALL, M. MONTEIL, G. GROUARD-VOGEL E. BERNIER, M. LECOUVEY, H. HLAWATY, S. MULLER, M-C. BOISSIER, E. ASSIER. Targeting VEGF-A with a vaccine decreases inflammation and joint destruction in experimental arthritis. Angiogenesis, 2016, 19, 39-52. Impact Factor 4.876

M. CORTES-CLERGET, O. GAGER, M. MONTEIL, J-L. PIRAT, E. MIGIANU-GRIFFONI, J. DESCHAMP, M. LECOUVEY. Novel Easily Recyclable Bifunctional Phosphonic Acid- Carrying Tripeptides for the Stereoselective Michael Addition of Aldehydes with Nitroalkenes Adv. Synth. Catal. 2016, 358, 34-40. Impact Factor 5.663


  S. KACHBI-KHELFALLAH, M. MONTEIL, J. DESCHAMP, O. GAGER, E. MIGIANU-GRIFFONI, M. LECOUVEY.Synthesis of novel polymerizable molecules bearing bisphosphonate. Org. Biomol. Chem. 2015,13, 11382-11392.Impact Factor 3.562

V. TOUM, J. BOLLEY, Y. LALATONNE, C. BARBEY, L. MOTTE, M. LECOUVEY, J. ROYER, N. DUPONT, J. PERARD-VIRET. In silico studies, synthesis and binding evaluation of substituted 2-pyrrolidinones as peptidominetics of RGD tripeptide sequence quinines and their cytotoxic effect on cancer cell lines. Eur. J. Med. Chem. 2015 93, 360-372. Impact Factor 3,432

E. PULJULA, P.A. TURBANEN, J. VEPSALAINEN, M. MONTEIL, M. LECOUVEY, J. WEISELL. Structural requirements for bisphosphonate binding on hydroxyapatite NMR study of bisphosphonate partial esters. ACS Med. Chem. Lett. 2015,6, 397-401. Impact Factor 3,073

R. BABOURI, M. ROLLAND, O. SAINTE-CATHERINE, Z. KABOUCHE, M. LECOUVEY, N. BAKALARA, J-N. VOLLE, D. VIRIEUX, J-L. PIRAT. α-Halogenated oxaphosphinanes: Synthesis, unexpected reactions and evaluation as inhibitors of cancer cell proliferation.Eur. J. Med. Chem. 2015 104, 33-41 Impact Factor 3,432

K.M. KONAN, J.A. MAMYRBEKOVA-BEKRO, J-L. PIRAT, D. VIRIEUX, M. LECOUVEY, Y.A. BEKRO. GC-MS analysis of total polyphenols extracted from the roots of Glyphaea brevis (Spreng.) MONACHINO (Tiliaceae) and assessment of their anti-proliferative activity. Phytothérapie, DOI 10.1007/s10298-014-0909-8.

A. H. O. N’GUESSAN, J. A. MAMYRBEKOVA-BEKRO, Y-A. BEKRO, J. L. PIRAT, D. VIRIEUX, E. MEUDEC, M. LECOUVEY.Analyse UPLC-MS/MS et activité antiproliférative de l’extrait brut hydroacétonique des feuilles de Alchornea cordifolia (Schum. & Thonn.) Müll. Arg. (Euphorbiaceae). Phytothérapie 2015, 13, 276-282.

S. GUEZANE LAKOUD, M. LECOUVEY, H. BERREBAH, N-E. AOUF. Synthesis of chiral phosphonoacetmides and their toxic effects on Paramecium sp. Org. Commun., 2015, 8, 1-8.


 L. CLARION, C. JACQUARD, O. SAINTE-CATHERINE, M. DECOUX, S. LOISEAU, M. ROLLAND, M. LECOUVEY, J.P. HUGNOT, J-N. VOLLE, D. VIRIEUX, J-L. PIRAT, N. BAKALARA. C-glycoside mimetics inhibit glioma stem cell proliferation, migration, and invasion. J Med Chem. 2014, 57, 8293-306. Impact Factor 5,207

M. MONTEIL, E. MIGIANU-GRIFFONI, O. SAINTE-CATHERINE, M. DI BENEDETTO, M. LECOUVEY. Bisphosphonate prodrugs: synthesis and biological evaluation in HuH7 hepatocarcinoma cells. Eur. J. Med. Chem. 2014, 77, 56-64. Impact factor 3,432

E. MIGIANU-GRIFFONI, I. CHEBBI, S. KACHBI, M. MONTEIL, O. SAINTE-CATHERINE, F. CHAUBET, O. OUDAR, M. LECOUVEY. Synthesis and biological evaluation of new bisphosphonate-dextran conjugates targeting breast primary tumor. Bioconjug. Chem. 2014, 25, 224-30. Impact Factor 4,82

F. DRIDI, N. BAR, O. SAINTE-CATHERINE, M. HACHEMI, M. LECOUVEY, D. VILLEMIN. Synthesis of new intercalated quinines and their cytotoxic effect on cancer cell lines. Eur. Chem. Bull. 2014, 3, 1020-1026. Impact Factor 2,583

K.V.C. N’GAMAN, G.R.M. KABRAN, B.A. KADJA, J.A. MAMYRBEKOVA-BEKRO, J-L. PIRAT, M. LECOUVEY, O. SAINTE-CATHERINE, N. SOMMERER, A. VERBAERE, E. MEUDEC, Y.A. BEKRO. UPLC-MS/MS phenolic quantification and in vitro anticancer potential of Gmelina arborea Roxb. (Verbenaceae). Pelagia Research Library. Der Chemica Sinica 2014, 5, 13-17. Impact Factor 0,516


 J. BOLLEY, E. GUENIN, N. LIEVRE, M. LECOUVEY, M. SOUSSAM, Y. LALATONNE, L. MOTTE. Carbodiimide versus click chemistry for nanoparticle surface functionalization: A comparative study for the elaboration of multimodal superparamagnetic nanoparticles Targeting αvβ3 Integrins. Langmuir 2013, 29, 14639-14647. Impact Factor 4,384

R. JANICKI, M.MONTEIL, M. LECOUVEY, A. MONDRY. Relations between structure and physico-optical properties of Eu3+ and Tb3+ tetraphosphonates. Optical Materials 2013, 36, 259-264. Impact Factor 2,2

R. BOUASLA, H. BERREDJEM, M. BERREDJEM, M. IBRAHIM-OUALID, A. ALLAOUI, M. LECOUVEY, N-E. AOUF. SynthesisandBiologicalActivityof NewChiralN-AcylsulfonamideBis-oxazolidin-2-ones. J.HeterocyclicChem. 2013, 50, 1328 -1332. Impact Factor 1,22


 L. CLARION, C. JACQUARD, O. SAINTE-CATHERINE, S. LOISEAU, D. FILIPPINI, M. H. HIRLEMANN, J-N. VOLLE, D. VIRIEUX, M. LECOUVEY, J-L. PIRAT, N. BAKALARA. Oxaphosphinanes : new therapeutic perspectives for glioblastoma. J. Med. Chem. 2012, 55, 2196-2211.Impact factor 5,207

C. DE MONTFERRAND, Y. LALATONNE, D. BONNIN, N. LIEVRE, M. LECOUVEY, P. MONOD, V. RUSSIER, L. MOTTE. Size-dependent nonlinear weak-field magnetic behavior of maghemite nanoparticles. Small 2012, 8, 1945-1956. Impact factor 7,333

B. ABECASSIS F., LEROUGE, F. BOUQUET, S. KACHBI, M. MONTEIL, P. DAVIDSON. Aqueous Suspensions of GdPO4 Nanorods: A Paramagnetic Mineral Liquid Crystal J. Phys. Chem. B. 2012, 116, 7590-7595 Impact Factor 3.6

C. BARBEY, R. BOUASLA, M. BERREDJEM, N. DUPONT, P. RETAILLEAU, N.E. AOUF, M. LECOUVEY. Synthesis and structural study of new substituted chiral sulfamoyl oxazolidin-2-ones. Tetrahedron 2012, 68, 9125-9130. Impact Factor 3,05

N. VINTONENKON, J.P. JAIS, N. KASSIS, M. ABDELKARIM, G.Y. PERRET, M. LECOUVEY, M. CREPIN, M. DI BENEDETTO. Transcriptome Analysis and In Vivo Activity of Fluvastatin versus Zoledronic Acid in a Murine Breast Cancer Metastasis Model. Mol. Pharmacol. 2012, 82, 521-528. Impact Factor 4.88