M. MONTEIL, H. MOUSTAOUI, G. PICARDI F. OUIDAT, N. DJAKER, M. LAMY DE LA CHAPELLE, M. LECOUVEY, J. SPADAVECCHIA. Polyphosphonate ligands: from synthesis to design of Hybrid PEGylated Nanoparticles toward phototherapy studies. J. Colloid Interface Sci. 2017 in press https://doi.org/10.1016/j.jcis.2017.10.055 Impact factor : 4,233

M.B. HADDADA, F. AOUIDAT, M. MONTEIL, M. LECOUVEY, M. LAMY DE LA CHAPELLE, J. SPADAVECCHIA. A simple assay for direct colorimetric detection of prostatic acid phosphatase (PAP) at fg levels using biphosphonated loaded PEGylated gold nanoparticles. Frontiers in Laboratory Medicine 2017 in press https://doi.org/10.1016/j.flm.2017.11.005

C. LINOT, J. POLY, J. BOUCARD, D. POULIQUEN, S. NEDELLEC, P. HULIN, N. MAREC, P. AROSIO, A. LASCIALFARI, A. GUERRINI, C. SANGREGORIO, M. LECOUVEY, L. LARTIGUE, C. BLANQUART, E. ISHOW. PEGylated Anionic Magnetofluorescent Nanoassemblies: Impact of Their Interface Structure on Magnetic Resonance Imaging Contrast and Cellular Uptake. ACS Appl. Mater. Interfaces 2017, 9, 14242-14257. Impact factor : 7,504

Z. HASSANI, A. SALEH, S. TURPAULT, S. KHIATI, W. MORELLE, J. VIGNON, J-P. HUGNOT, E. URO-COSTE, P. LEGRAND, M. DELAFORGE, S. LOISEAU, L. CLARION, M. LECOUVEY, J-N VOLLE, D. VIRIEUX, J-L PIRAT, H. DUFFAU, N. BAKALARA. Phostine PST3.1a Targets MGAT5 and Inhibits Glioblastoma Initiating Cell Invasiveness and Proliferation . Impact factor : 4,974

M. CORTES-CLERGET, J. JOVER, J. DUSSART, E. KOLODZIEJ, M. MONTEIL, E. MIGIANU-GRIFFONI, O. GAGER, J. DESCHAMP, M. LECOUVEY. Bifunctional Tripeptide with a Phosphonic Acid as a Brønsted Acid for Michael Addition: Mechanistic Insights. Chem. Eur. J. 2017, 23, 6654-6662. Impact factor : 5,771

M . MONTEIL, M. LECOUVEY, D. LANDY, S. RUELLAN, I. MALLARD. Cyclodextrins: A promising drug delivery vehicle for bisphosphonate. Carbohydrate Polymers 2017 156, 285-293. Impact factor : 4,811

GRM KABRAN, JA MAMYRBEKOVA-BEKRO, JL PIRAT, M LECOUVEY, O SAINTE-CATHERINE, N SOMMERER, A VERBAERE, EMEUDEC, YA BEKRO. UPLC-MS quantification and Anticancer Potential of Ximenia Americana Hydro-Acetonic Crude Extract Leaves.Der Chemica Sinica 2017, 8, 70-74. Impact Factor 0,676


S. KACHBI-KHELFALLAH, M. MONTEIL, M. CORTES-CLERGET, E. MIGIANU-GRIFFONI, J-L. PIRAT, O. GAGER, J. DESCHAMP, M. LECOUVEY. Towards potential nanoparticle contrast agents: Synthesis of new functionalized PEG bisphosphonates. Beilstein J. Org. Chem. 2016, 12, 1366-1371. Impact Factor 2.7

A. B. KADJA, Y-A. BEKRO, J-L. PIRAT, J. AKHANOVNA MAMYRBEKOVA-BEKRO, J-N. VOLLE, M. LECOUVEY, M-H. BOYER-LAVERGNE. Chemical Constituents and in Vitro Biological Screening of Hydroacetonic Extracts of 3 African Toothpicks. International Journal of Green and Herbal Chemistry (IJGHC) 2016 ; Sec. A; 5, 201-208 Impact Factor 1.8

L. SEMERANO , E. DUVALLET, N. BELMELLAT, N. MARIVAL, N. SCHALL, M. MONTEIL, G. GROUARD-VOGEL E. BERNIER, M. LECOUVEY, H. HLAWATY, S. MULLER, M-C. BOISSIER, E. ASSIER. Targeting VEGF-A with a vaccine decreases inflammation and joint destruction in experimental arthritis. Angiogenesis, 2016, 19, 39-52. Impact Factor 4.876

M. CORTES-CLERGET, O. GAGER, M. MONTEIL, J-L. PIRAT, E. MIGIANU-GRIFFONI, J. DESCHAMP, M. LECOUVEY. Novel Easily Recyclable Bifunctional Phosphonic Acid- Carrying Tripeptides for the Stereoselective Michael Addition of Aldehydes with Nitroalkenes Adv. Synth. Catal. 2016, 358, 34-40. Impact Factor 5.663


  S. KACHBI-KHELFALLAH, M. MONTEIL, J. DESCHAMP, O. GAGER, E. MIGIANU-GRIFFONI, M. LECOUVEY.Synthesis of novel polymerizable molecules bearing bisphosphonate. Org. Biomol. Chem. 2015,13, 11382-11392.Impact Factor 3.562

V. TOUM, J. BOLLEY, Y. LALATONNE, C. BARBEY, L. MOTTE, M. LECOUVEY, J. ROYER, N. DUPONT, J. PERARD-VIRET. In silico studies, synthesis and binding evaluation of substituted 2-pyrrolidinones as peptidominetics of RGD tripeptide sequence quinines and their cytotoxic effect on cancer cell lines. Eur. J. Med. Chem. 2015 93, 360-372. Impact Factor 3,432

E. PULJULA, P.A. TURBANEN, J. VEPSALAINEN, M. MONTEIL, M. LECOUVEY, J. WEISELL. Structural requirements for bisphosphonate binding on hydroxyapatite NMR study of bisphosphonate partial esters. ACS Med. Chem. Lett. 2015,6, 397-401. Impact Factor 3,073

R. BABOURI, M. ROLLAND, O. SAINTE-CATHERINE, Z. KABOUCHE, M. LECOUVEY, N. BAKALARA, J-N. VOLLE, D. VIRIEUX, J-L. PIRAT. α-Halogenated oxaphosphinanes: Synthesis, unexpected reactions and evaluation as inhibitors of cancer cell proliferation.Eur. J. Med. Chem. 2015 104, 33-41 Impact Factor 3,432

K.M. KONAN, J.A. MAMYRBEKOVA-BEKRO, J-L. PIRAT, D. VIRIEUX, M. LECOUVEY, Y.A. BEKRO. GC-MS analysis of total polyphenols extracted from the roots of Glyphaea brevis (Spreng.) MONACHINO (Tiliaceae) and assessment of their anti-proliferative activity. Phytothérapie, DOI 10.1007/s10298-014-0909-8.

A. H. O. N’GUESSAN, J. A. MAMYRBEKOVA-BEKRO, Y-A. BEKRO, J. L. PIRAT, D. VIRIEUX, E. MEUDEC, M. LECOUVEY.Analyse UPLC-MS/MS et activité antiproliférative de l’extrait brut hydroacétonique des feuilles de Alchornea cordifolia (Schum. & Thonn.) Müll. Arg. (Euphorbiaceae). Phytothérapie 2015, 13, 276-282.

S. GUEZANE LAKOUD, M. LECOUVEY, H. BERREBAH, N-E. AOUF. Synthesis of chiral phosphonoacetmides and their toxic effects on Paramecium sp. Org. Commun., 2015, 8, 1-8.


 L. CLARION, C. JACQUARD, O. SAINTE-CATHERINE, M. DECOUX, S. LOISEAU, M. ROLLAND, M. LECOUVEY, J.P. HUGNOT, J-N. VOLLE, D. VIRIEUX, J-L. PIRAT, N. BAKALARA. C-glycoside mimetics inhibit glioma stem cell proliferation, migration, and invasion. J Med Chem. 2014, 57, 8293-306. Impact Factor 5,207

M. MONTEIL, E. MIGIANU-GRIFFONI, O. SAINTE-CATHERINE, M. DI BENEDETTO, M. LECOUVEY. Bisphosphonate prodrugs: synthesis and biological evaluation in HuH7 hepatocarcinoma cells. Eur. J. Med. Chem. 2014, 77, 56-64. Impact factor 3,432

E. MIGIANU-GRIFFONI, I. CHEBBI, S. KACHBI, M. MONTEIL, O. SAINTE-CATHERINE, F. CHAUBET, O. OUDAR, M. LECOUVEY. Synthesis and biological evaluation of new bisphosphonate-dextran conjugates targeting breast primary tumor. Bioconjug. Chem. 2014, 25, 224-30. Impact Factor 4,82

F. DRIDI, N. BAR, O. SAINTE-CATHERINE, M. HACHEMI, M. LECOUVEY, D. VILLEMIN. Synthesis of new intercalated quinines and their cytotoxic effect on cancer cell lines. Eur. Chem. Bull. 2014, 3, 1020-1026. Impact Factor 2,583

K.V.C. N’GAMAN, G.R.M. KABRAN, B.A. KADJA, J.A. MAMYRBEKOVA-BEKRO, J-L. PIRAT, M. LECOUVEY, O. SAINTE-CATHERINE, N. SOMMERER, A. VERBAERE, E. MEUDEC, Y.A. BEKRO. UPLC-MS/MS phenolic quantification and in vitro anticancer potential of Gmelina arborea Roxb. (Verbenaceae). Pelagia Research Library. Der Chemica Sinica 2014, 5, 13-17. Impact Factor 0,516


 J. BOLLEY, E. GUENIN, N. LIEVRE, M. LECOUVEY, M. SOUSSAM, Y. LALATONNE, L. MOTTE. Carbodiimide versus click chemistry for nanoparticle surface functionalization: A comparative study for the elaboration of multimodal superparamagnetic nanoparticles Targeting αvβ3 Integrins. Langmuir 2013, 29, 14639-14647. Impact Factor 4,384

R. JANICKI, M.MONTEIL, M. LECOUVEY, A. MONDRY. Relations between structure and physico-optical properties of Eu3+ and Tb3+ tetraphosphonates. Optical Materials 2013, 36, 259-264. Impact Factor 2,2

R. BOUASLA, H. BERREDJEM, M. BERREDJEM, M. IBRAHIM-OUALID, A. ALLAOUI, M. LECOUVEY, N-E. AOUF. SynthesisandBiologicalActivityof NewChiralN-AcylsulfonamideBis-oxazolidin-2-ones. J.HeterocyclicChem. 2013, 50, 1328 -1332. Impact Factor 1,22


 L. CLARION, C. JACQUARD, O. SAINTE-CATHERINE, S. LOISEAU, D. FILIPPINI, M. H. HIRLEMANN, J-N. VOLLE, D. VIRIEUX, M. LECOUVEY, J-L. PIRAT, N. BAKALARA. Oxaphosphinanes : new therapeutic perspectives for glioblastoma. J. Med. Chem. 2012, 55, 2196-2211.Impact factor 5,207

C. DE MONTFERRAND, Y. LALATONNE, D. BONNIN, N. LIEVRE, M. LECOUVEY, P. MONOD, V. RUSSIER, L. MOTTE. Size-dependent nonlinear weak-field magnetic behavior of maghemite nanoparticles. Small 2012, 8, 1945-1956. Impact factor 7,333

B. ABECASSIS F., LEROUGE, F. BOUQUET, S. KACHBI, M. MONTEIL, P. DAVIDSON. Aqueous Suspensions of GdPO4 Nanorods: A Paramagnetic Mineral Liquid Crystal J. Phys. Chem. B. 2012, 116, 7590-7595 Impact Factor 3.6

C. BARBEY, R. BOUASLA, M. BERREDJEM, N. DUPONT, P. RETAILLEAU, N.E. AOUF, M. LECOUVEY. Synthesis and structural study of new substituted chiral sulfamoyl oxazolidin-2-ones. Tetrahedron 2012, 68, 9125-9130. Impact Factor 3,05

N. VINTONENKON, J.P. JAIS, N. KASSIS, M. ABDELKARIM, G.Y. PERRET, M. LECOUVEY, M. CREPIN, M. DI BENEDETTO. Transcriptome Analysis and In Vivo Activity of Fluvastatin versus Zoledronic Acid in a Murine Breast Cancer Metastasis Model. Mol. Pharmacol. 2012, 82, 521-528. Impact Factor 4.88

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