Team LBPS - CSPBAT- UMR 7244

Institut Galilée, Batiment E 4ème étage (Bureau E 405)
99 Avenue JB Clément
93430 Villetaneuse (France)
Tel : +33 (0)1 49 40 33 52 (3346)

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Véronique Migonney received an Engineer Diploma in Materials Sciences (1981), a Master in Biomedical and Biomaterials Engineering (1982) and a PhD (1986) in Chemistry (Doctorat d’Etat Es Sciences Physiques spécialité Chimie – supervisor M. Jozefowicz) from University Paris 13th. Véronique Migonney was director of the laboratory CSPBAT UMR 7244 CNRS UP13 from 2009 to 2016 and heads the team LBPS devoted to Biomaterials Sciences from 2002. She set up and headed the Master of Chemistry and Health Engineering from 2004 to 2016. Véronique Migonney is Fellow of the International College of Fellows in Biomaterials Science and Engineering for her contribution to the functionalization of biomaterials surfaces. She was president of the French Society for Biomedical Engineering 2011-2013 and she is vice-president of the AGBM (Alliance pour le Génie Biologique et Médical). Her expertise is focused on biomaterials science: she is working for > 40 years in the field of bioactive polymers synthesis and grafting to functionalize biomaterials surfaces with the aim of controlling the host response.



Themes of research

Chemistry of Biomaterials
Functionalization of polymeric and metallic surfaces by polymer grafting techniques
Bioactive surfaces and control of the host response
Bioactive implants and prostheses for orthopedic applications

Significant Publications ( 2013 - today)


 Different real-time degradation scenarios of functionalized Poly(ε-caprolactone) for biomedical applications,
J. Appl.Poly. Sci. 2021, in press
 Biomaterial-assisted gene therapy for translational approaches to treat musculoskeletal disorders,
Mat Today Adv 2021,9, 100126


 Review of silicone surface modification techniques and coatings for antibacterial/antimicrobial applications to improve breast implant surfaces,
Biomatériaux, polymères bioactifs et implants innovants : la nécessaire biodégradabilité.
Actualité chimique 2020; 456 - 458, 186
Long-term Hydrolytic Degradation Study of Polycaprolactone Films and Fibers Grafted with Poly(sodium styrene sulfonate) : Mechanism Study and Cell Response.
Biointerphases 2020 ;15, 061006, doi: 10.1116/6.0000429
 Chondrogenic differentiation of human bone marrow aspirates enhanced by overexpression of RAAV- SOX9 and TGF-B upon vector delivery via pnass-grafted microstructured poly(E-caprolactone) scaffolds,
Osteoarthritis and Cartilage 2020, 28, S520-S521. DOI:10.1016/j.joca.2020.02.818 Impact Factor: 5,454

 Kinetic and degradation reactions of poly (sodium 4-styrene sulfonate) grafting "from" ozonized poly (ɛ- caprolactone) surfaces,
Polymer Degradation and Stability 2020, 176, 109154,DOI : 10.1016/j.polymdegradstab.2020.109154 , Impact Factor 3,78


Thiol-Poly (Sodium Styrene Sulfonate)(PolyNaSS-SH) Gold Complexes: From a Chemical Design to a One-Step Synthesis of Hybrid Gold Nanoparticles and Their Interaction with Human Proteins,
 Falentin-Daudré C.,  Aitouakli M.., Baumann J.S.,  Bouchemal N., Humblot V.,  Migonney V.,  Spadavecchia J.,
ACS omega 2020; (5), 8137−8145
Kinetic and degradation reactions of poly (sodium 4-styrene sulfonate) grafting “from” ozonized poly (ɛ-caprolactone) surfaces,
Nguyen N.T.,  Rangel A.L.R., Migonney V,
Polymer Degradation and Stability 2020; (176), 109154;

A simple way to graft a bioactive polymer – Polystyrene sodium sulfonate on silicone surfaces 
Lam M., Moris V.,Humblot V., Migonney V., Falentin-Daudre C.
European Polymer Journal, 2020, 128,109608.  https://doi.org/10.1016/j.eurpolymj.2020.109608
Microstructure and biological evaluation of nanocrystalline diamond films deposited on titanium substrates using distributed antenna array microwave system
Dekkar D., Bénédic F., Falentin-Daudré C., Rangel A., Issaoui R., Migonney V., Achard J.
Diamond and Related Materials 2020, https://doi.org/10.1016/j.diamond.2020.107700.
Enhanced Chondrogenic Differentiation Activities in Human Bone Marrow Aspirates via sox9Overexpression Mediated by pNaSS-Grafted PCL Film-Guided rAAV Gene Transfer,
 Venkatesan J.K.,  Meng W., Rey-Rico A. , Schmitt G.,  Speicher-Ment S.,  Falentin-Daudré C., Leroux A., Madry H.,  Migonney V.,  Cucchiarini M., 
Pharmaceutics 2020; 12(3), 280;
Nanostructured titanium alloy surfaces for enhanced osteoblast response: A combination of morphology and chemistry.
Rangel A.L.R. ,  Falentin-DAUDRÉ C.,  Pimentel B.N.A. S., Vergani C.E., Migonney  V., Alves Claro A.P.R.   
Surface and Coatings Technology, 2020, 383,125226   DOI :10.1016/j.surfcoat.2019.125226

2019 :

Biomaterial-Guided rAAV Delivery from pNaSS-Grafted PCL Films to Target Human Bone Marrow Aspirates
Venkatesan J. K.,  Falentin-Daudré C.,  Leroux, A.,  Migonney V.,  Cucchiarini M.
Tissue Engineering Part A ,  2019 , https://doi.org/10.1089/ten.TEA.2019.0165
Electrospun Poly(ε-caprolactone) Fiber Scaffolds Functionalized by the Covalent Grafting of a Bioactive Polymer: Surface Characterization and Influence on in Vitro Biological Response
Amokrane G., Humblot V., Jubeli E.,  Yagoubi N., Ramtani S., Migonney V., ́  Falentin-Daudre ́ C.
ACS Omega 2019, 4, 17, 17194-17208
Analysis of early cellular responses of anterior cruciate ligament fibroblasts seeded on different molecular weight polycaprolactone films functionalized by a bioactive poly(sodium styrene sulfonate) polymer
Leroux A.,  Venkatesan J. K,  Castner D.G., Cucchiarini M.,  Migonney V.
Biointerphases 2019, 14, 041004, ;https://doi.org/10.1116/1.5102150
OverexpreA.ssion of rAAV-SOX9 and TGF-B in human bone marrow aspirates upon vector delivery via pNaSS-coated poly(e-caprolactone) scaffolds
Venkatesan J.K., Falentin-Daudré C., Leroux A., .Baumann J.-S, Migonney V., Cucchiarini M.,
Osteoarthritis and Cartilage, 2019, 27, S149-S150
Review of titanium surface modification techniques and coatings for antibacterial applications.
Falentin-Daudré C.,  Chouirfa H., H Bouloussa, Migonney V.;
 Acta Biomaterialia 2019  83,37-57
Feasibility study of the elaboration of a biodegradable and bioactive ligament made of poly(ε-caprolactone)-pNaSS grafted fibers for the reconstruction of anterior cruciate ligament: in vivo experiment.
Leroux A.,  Maurice E.,  Viateau V.,  Migonney V.;
IRBM 2019 40,38-44
2018 :
Impact of chemical and physical treatments on the mechanical properties of poly(ε-caprolactone) fibers bundles for the anterior cruciate ligament reconstruction
Leroux A.,  Egles C.,  Migonney V.;
Plos One 2018 https://doi.org/10.1371/journal.pone.0205722
A simple way to functionalize PCL surface by grafting bioactive polymers using UV irradiation
Amokrane G. ; Falentin-Daudré C.* ; Ramtani S. ; Migonney V.
IRBM, 2018, 39 (4), 268-278.

Genetic modification of human bone marrow aspirates via delivery of rAAV vectors coated on on pNaSS-grafted poly(ε-caprolactone) scaffolds
Venkatesan J. K., Leroux A., Baumann J.-S., Rey-Rico A., Falentin-Daudré C., Frisch J., Madry H., Migonney V., Cucchiarini M.
Osteoarthritis and Cartilage, 2018, 26 (1), S134-S135.

Controlled Release of Gene Therapy Constructs from Solid Scaffolds for Therapeutic Applications in Orthopedics
Venkatesan J., Falentin-Daudré C., Leroux A., Migonney V., Cucchiarini M.
Discovery Medicine, 2018, 25 (138), 195-203. 

Grafting of bioactive polymers with various architectures: a versatile tool for preparing antibacterial infection and biocompatible surfaces,
Chouirfa H., Evans M. D.M., Bean P., Saleh-Mghir A., Crémieux A.C., Castner D.G., Falentin-Daudré C., Migonney V.
ACS Appl. Mater. Interfaces, 2018, 10(2), pp 1480–1491

Grafting of bioactive polymers with various architectures: a versatile tool for preparing antibacterial infection and biocompatible surface.Hamza Chouirfa, Margaret D. M. Evans, Penny Bean, Azzam Saleh-Mghir, Anne Claude Crémieux,David G. Castner, Céline Falentin-Daudré, Véronique Migonney
ACS Appl Mater Interfaces. 2018; 10:1480-1491
Highly crystalline sphere and rod-shaped TiO 2 nanoparticles: A facile route to bio-polymer grafting
C Falentin-Daudré, JS Baumann, V Migonney, J Spadavecchia,
Frontiers in Laboratory Medicine. 2017 1 (4), 217-223

 Grafting of architecture controlled poly(styrene sodium sulfonate) onto titanium surfaces using bio-adhesive molecules: Surface characterization and biological properties
Chouirfa H, Evans MDM, Castner DG, Bean P, Mercier D, Galtayries A, Falentin-Daudré C, Migonney V.
Biointerphases. 2017 Jun 14;12(2):02C418. doi: 10.1116/1.4985608.
Functionalization of NewBiocompatible Titanium Alloys with Harmonic Structure Design by Using UV IrradiatioN,
G Amokrane, A Hocini, K Ameyama, G Dirras, V Migonney,
IRBM 2017. 38 (4), 190-197,
 Bone tissue response induced by bioactive polymer functionalized Ti6Al4V surfaces: In vitro and in vivo study,
HP Felgueiras, A Decambron, M Manassero, L Tulasne, MDM Evans, V Migonney,
Journal of Colloid and Interface Science 2017; 491: 44-54,
Competitive adsorption of plasma proteins using quartz crystal microbalance.
Felgueiras HP, Sanjeeva NS, Sommerfeld SD, Brás M, Migonney V, Kohn J.
Appl Mater Interfaces. 2016; 8:13207-13217.

Grafting bioactive polymers onto titanium implants by UV irradiation,
H Chouirfa, V Migonney, C Falentin-Daudré ,
RSC Advances 2016 6 (17), 13766-13771

  Contributions of adhesive proteins to the cell and bacteria response to surfaces treated with bioactive polymers: case of poly(sodium styrene sulfonate) grafted titanium surfaces.

Felgueiras HP, Ben Aissa I, Evans MD, Migonney V.
J Mater Sci Mater Med. 2015; 26:261-275.

 The grafting of a thin layer of poly(sodium styrene sulfonate) onto poly(ε-caprolactone) surface can enhance fibroblast behavior,.
Rohman, G., Huot, S., Vilas-Boas, M., Radu-Bostan, G., Castner, DG, Migonney, V
J Mater Sci Mater Med. 26(7):206. 2015.
 Contributions of adhesive proteins to the cell and bacteria response to surfaces treated with bioactive polymers: case of poly(sodium styrene sulfonate) grafted titanium surfaces,
Felgueiras, H., Ben Aissa, I., Evans, M., Migonney, V.,
J Mater Sci Mater Med., 26(11):261, 2015
.,Contribution of fibronectin and vitronectin to the adhesion and morphology of MC3T3-E1 osteoblastic cells to poly(NaSS) grafted Ti6Al4V
Felgueiras, H., Evans, M., Migonney, V
Acta. Biomat, 28:225-33, 2015
,Biomechanical evaluation of a bioactive artificial anterior cruciate ligament.
S. Guérard, M. Manassero, V. Viateau, V. Migonney, W. Skalli, D. Mitton
Advances in Biomechanics & Applications, An International Journal" 2015, 1 (4) ; 239-252
 Role of protein environment and bioactive polymer grafting in the S. epidermidis response to titanium alloy for biomedical applications,
D.M. Vasconcelos, C. Falentin-Daudré, D. Blanquaert, D. Thomas, P. L. Granja, V. Migonney.
Materials Science and Engineering: C, 2014 Dec ;45 :176-183

 Poly(NaSS) Functionalization Modulates the Conformation of Fibronectin and Collagen Type I To Enhance Osteoblastic Cell Attachment onto Ti6Al4V,
Felgueiras HP, Sommerfeld SD, Murthy NS, Kohn J, Migonney V.
Langmuir. 2014 Aug 12;30(31):9477-83

  Grafting titanium nitride surfaces with sodium styrene sulfonate thin films",
G. Zorn, V. Migonney, D. Castner.
Biointerphases 2014 ; 9 (3)

Sulfonate groups grafted on Ti6Al4V favor MC3T3-E1 cell performance in serum free medium conditions,
Felgueiras H, Migonney V.
Materials Science and Engineering: C 2014. ; 39, 196-202

Characterization of a synthetic bioactive polymer by nonlinear optical microscopy,
Djaker N, Brustlein S, Rohman G, Huot S, de la Chapelle ML, Migonney V,
Biomed Opt Express. 2014; 5(1):149-57.
 The effect of polystyrene sodium sulfonate grafting on polyethylene terephthalate artificial ligaments on in vitro mineralization and in vivo bone tissue integration
C. Vaquette, V. Viateau, S. Guérard, F. Anagnostou, M. Manassero, D.G. Castner, V. Migonney,
Biomaterials 2013 34(29) 7048-6

 Increasing the bioactivity of elastomeric poly(ε-caprolactone) scaffolds for use in tissue engineering
,Huot S, Rohman G, Riffault M, Pinzano A, Grossin L, Migonney V.
Biomed Mater Eng. 2013;23(4):281-8.

 Biological and biomechanical evaluation of the ligament advanced reinforcement system (LARS AC) in a sheep model of anterior cruciate ligament replacement: a 3-month and 12-month study,
Viateau V, Manassero M, Anagnostou F, Guérard S, Mitton D, Migonney V.
Arthroscopy. 2013 Jun;29(6):1079-88

A PolyNaSS grafting on titanium surfaces enhances osteoblast differentiation a nd inhibits Staphylococcus aureus adhésion,
lcheikh A, Pavon-Djavid G, Helary G, Petite H, Migonney V, Anagnostou F. J
Mater Sci Mater Med. 2013 Jul;24(7):1745-54.


Books and book chapters

Edition de l’ouvrage “Biomaterials”, V. Migonney, ISTE - Wyley, 2014 November, ISBN: 978-1-84821-585-6, 248 pages
Migonney V. Chap 1 « History of Biomaterials », Véronique Migonney in Biomaterials, ISTE - Wyley, (2014) ISBN: 978-1-84821-585-6, pp 1-10 (2014)
Migonney V Chap 2 « Definitions », Véronique Migonney in Biomaterials, ISTE - Wyley(2014) ISBN: 978-1-84821-585-6, pp 11-24
Migonney V « Biocompatibility and Norms », Véronique Migonney in Biomaterials, ISTE – Wyley, (2014) ISBN: 978-1-84821-585-6, pp 83-98
Migonney V « Bioactive Polymers and Surfaces: A Solution for Implant Devices », Véronique Migonney in Biomaterials, ISTE - Wyley, (2014) ISBN: 978-1-84821-585-6, pp 101-113

Scientific Production
Patents: 23
Publications: >130 articles, 14 proceedings, >150 communications, 80 invited communications, 10 book chapters

Macromolecular chemistry, Biomaterials Science, Biocompatibility, Host response

Industrial Partnership
LARS, Ceraver, Iceram, texinov

Scientific programs
BPI granted LIGA2BIO: UP13, Lars, Texinov + UTC, ENSAM, UPMC, ENVA