PALAMAMaître de conférences (Assistant Professor)

Equipe SBMB - CSPBAT-UMR 7244
UFR Santé, Médecine, Biologie Humaine Université Paris 13 (Bureau 344)
74 rue Marcel Cachin
93017 Bobigny Cedex (France)
Tel: 01 48 38 76 91

tony.palama (at) univ-paris13.fr
 

Biography


Tony Palama studied biology at University of La Réunion and University of Montpellier 2. He obtained a Licence in Cell Biology and Physiology (in 2003) and a Master in Plant Genomics and Advanced Technologies (in 2006). Tony has continued his interest in biology, chemistry and physics by spending some years in The Netherlands where he started a sandwich PhD between Universiteit Leiden (NL) and Université de La Réunion (FR). He was supervised by Prof. Robert Verpoorte (Head of the Pharmacognosie group, Leiden) and Dr. Hippolyte Kodja (UMR PVBMT, La Réunion). His PhD thesis, entitled “Nuclear Magnetic Resonance (NMR)-based metabolomics characterization of Vanilla planifolia”, was defended on the 10th of June 2010, in Leiden.
After his PhD, Tony returned to La Réunion as a post-doctoral researcher at the GIP CYROI to continue his research on the characterization of vanilla and others aromatic and medicinal plants. The skills he developed in NMR-based metabolomics were efficiently employed in a second post-doc where he made the discrimination of bacteria species using the analysis of culture supernatant by NMR spectroscopy. This work was performed at the High-Field NMR Center in Villeurbanne (FR) under the supervision of Dr. Bénédicte Elena-Herrmann and worked in collaboration with BioMérieux Lab. Then, in Toulouse (FR), Tony got the opportunity to work on the metabolomic and fluxomic study of cancer cells as a research engineer with support of Canceropole GSO at the MetaToul platform. During this period, he developed skills and expertise in 13C-labelling experiments, flux analysis and metabolic network visualization.
Since September 2017, Tony Palama has an assistant-professor position at Université Paris 13, in Bobigny. He is conducting research in Clinical Metabolomics by joining the team of Prof. Philippe Savarin from the « Chimie Structures et Propriétés de Biomatériaux et d’Agents Thérapeutiques » CSPBAT laboratory.  

 
Research

Keywords


Metabolomics, Metabolic Network, Fluxomics - NMR spectroscopy, Mass spectometry - Plant, Bacteria, Cancer, Human cell

Recent publications

  • Chemotherapy Resistant Human Acute Myeloid Leukemia Cells are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism. Farge, T., E. Saland, F. de Toni, N. Aroua, M. Hosseini, R. Perry, C. Bosc, M. Sugita, L. Stuani, M. Fraisse, S. Scotland, C. Larrue, H. Boutzen, V. Féliu, M.-L. Nicolau-Travers, S. Cassant-Sourdy, N. Broin, M. David, N. Serhan, A. Sarry, S. Tavitian, T. Kaoma, L. Vallar, J. Iacovoni, L. K. Linares, C. Montersino, R. Castellano, E. Griessinger, Y. Collette, O. Duchamp, Y. Barreira, P. Hirsch, T. Palama, L. Gales, F. Delhommeau, B. H. Garmy-Susini, J.-C. Portais, F. Vergez, M. Selak, G. Danet-Desnoyers, M. Carroll, C. Récher and J. E. Sarry, Cancer Discovery 7(7): 716-735, 2017. 
  • High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells. Poulain, L., P. Sujobert, F. Zylbersztejn, S. Barreau, L. Stuani, M. Lambert, T. L. Palama, V. Chesnais, R. Birsen, F. Vergez, T. Farge, C. Chenevier-Gobeaux, M. Fraisse, F. Bouillaud, C. Debeissat, O. Herault, C. Recher, C. Lacombe, M. Fontenay, P. Mayeux, T. T. Maciel, J. C. Portais, J. E. Sarry, J. Tamburini, D. Bouscary and N. Chapuis, Leukemia: 1-10, 2017. 
  • Identification of bacterial species by untargeted NMR spectroscopy of the exo-metabolome. Palama, T. L., I. Canard, G. J. P. Rautureau, C. Mirande, S. Chatellier and B. Elena-Herrmann, Analyst 141(15): 4558-4561, 2016.
  • Insights on the virulence of swine respiratory tract mycoplasmas through genome-scale metabolic modeling. Ferrarini, M. G., F. M. Siqueira, S. G. Mucha, T. L. Palama, É. Jobard, B. Elena-Herrmann, A. T. R. Vasconcelos, F. Tardy, I. S. Schrank, A. Zaha and M.-F. Sagot, BMC Genomics 17(1): 353, 2016.
  • Biochemical characterization of embryogenic calli of Vanilla planifolia in response to two years of thidiazuron treatment. Kodja, H., M. Noirot, S. S. Khoyratty, H. Limbada, R. Verpoorte and T. L. Palama, Plant Physiology and Biochemistry 96: 337-344, 2015.
  • Fungal endophytes of Vanilla planifolia across Réunion Island: isolation, distribution and biotransformation. Khoyratty, S., J. Dupont, S. Lacoste, T. L. Palama, Y. H. Choi, H. K. Kim, B. Payet, M. Grisoni, M. Fouillaud, R. Verpoorte and H. Kodja, BMC Plant Biology 15(1): 1-19, 2015.
  • Expression profiles of key phenylpropanoid genes during Vanilla planifolia pod development reveal a positive correlation between PAL gene expression and vanillin biosynthesis. Fock-Bastide, I., T. L. Palama, S. Bory, A. Lécolier, M. Noirot and T. Joët, Plant Physiology and Biochemistry 74(0): 304-314, 2014.

Book chapter

  • Metabolomic analysis of a commercially important aromatic plant from the Indian Ocean: Vanilla planifolia. Palama, T. L., In Novel Plant Bioressources - Applications in Food, Medicine and Cosmetics, Gurib-Fakim, A., Ed. John Wiley & Sons, Ltd: Chichester, UK, 2014.

Patent

  • Procédé de discrimination des bactéries Escherichia coli et Shigella par spectrométrie RMN. Canard, I.; Elena-Herrmann, B.; Mirande, C.; Palama, T.; Rautureau, G. WO2016198789 A1, 2016-12-15, 2016.

 

Teaching (UnivParis13, UFR SMBH, Bobigny)

Licence Science de la Vie

- Physique optique (L1)
- Optique ondulatoire (L2)
- Projet expérimental instrumentation et techniques d’analyses (L3)

Master Biologie Santé - spécialité Thérapies et Technologies du Vivant

- Projet expérimental en méthode d’analyse (M1)
- Métabolomique (M2)